Dr. Douglas Kinghorn
The Environmental & Plant Biology Colloquium Series presents Dr. A. Douglas Kinghorn on “Tropical Plants from Southeast Asia as Sources of Antineoplastic Lead Compounds” on Friday, Oct. 28, at 11:50 a.m. in Porter Hall 104.
Kinghorn is Professor and Jack L. Beal Chair in the College of Pharmacy at The Ohio State University.
Abstract: Single chemical entity (SCE) anticancer agents from plants have been a mainstay of cancer chemotherapy for more than 50 years, inclusive of representatives of the bisindole alkaloid, camptothecin, lignan, and taxane diterpene compound classes. Recent approvals of plant-derived compounds as anticancer agents in the United States include cabazitaxel (for hormone-refractory metastatic prostate cancer in combination with prednisone) and omacetaxine mepesuccinate (for chronic myeloid leukemia). In this presentation, the organization of a multidisciplinary natural products drug discovery research program, funded through the NIH/NCI “program project” model, will be described, involving collaborators from both academic and industrial laboratories. The overall objective of this program is the discovery of new anticancer agent lead compounds from tropical plants, aquatic cyanobacteria, and filamentous fungi. Progress made in elucidating new lead compounds with antineoplastic activity from higher plants collected in southeast Asia will be described. Compounds to be discussed are the cardiac glycoside, strebloside, from Streblus asper, the diphyllin lignin glycosides, phyllanthusmins C and D, isolated from Phyllanthus poilanei, and the cyclopenta[b]benzofuran, silvestrol, a constituent of Aglaia foveolata.
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