Note: This event has been canceled.
The Environmental & Plant Biology Colloquium Series presents Dr. Richard Marshall on “Autophagic Degradation of Macromolecular Complexes: from Plant to Human Disease” on Friday, April 10, at 11:50 a.m. in Porter 104.
Marshall is a professor for the Department of Biology at Washington University at St. Louis.
Abstract: Maintenance of proteostasis is central to cellular fitness and is achieved through sophisticated protein quality control pathways that remove dysfunctional or unwanted proteins and protein complexes. When these pathways are impaired, deleterious protein aggregates often accumulate, which can be hallmarks of aging, cancer and numerous human aggregation-prone pathologies. One major quality control and recycling pathway in eukaryotes is autophagy, where unwanted cytoplasmic material is encapsulated into a double membrane-bound vesicle and delivered to the vacuole or lysosome for breakdown. During autophagy, the ubiquitin-fold protein ATG8 associates with the expanding autophagic membrane to provide a docking platform for receptors that recruit specific cargo. My research has identified evolutionarily conserved pathways for autophagic degradation of macromolecular complexes such as proteasomes, ribosomes and CDC48. I will describe the discovery of these pathways, and their relevance to both plant growth and development, and human health and disease.
Comments