An intriguing concept of prion-like spreading of pathogenic proteins has recently emerged, that has the potential to transform neurodegeneration research. Abundant neuronal protein a-synuclein (a-Syn) is a pathogenic protein that forms the abnormal accumulation of protein aggregates, called Lewy bodies (LBs) and causes several neurodegenerative diseases including Parkinson’s disease (PD).
Using fruit flies due to their genomic similarities to humans, we aim to better understand how a-Syn spreads between neurons and what molecular factors influence the transmission of the protein. We strongly believe new insights into the molecular mechanisms of a-Syn propagation will uncover potential therapeutic targets for slowing or even halting PD progression.
Sazan Ismael, Daewoo Lee, Sarah Baitamouni
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