The Chemistry & Biochemistry Colloquium Series presents Dr. Garth Simpson, on”Quantitative Nonlinear Optical Imaging” on Feb. 5, from 4:10 to 5 p.m. in Clippinger 194.
Dr. Garth Simpson
Simpson is Professor of Analytical and Physical Chemistry at Purdue University.
The host is Dr. Anthony Stender.
Abstract: The increasing availability of ultrafast laser sources provides ever broadening access to nontraditional light/matter interactions scaling nonlinearly with incident intensity, applications of which are described for addressing crystal analyses in structural biology and pharmaceutical sciences. In structural biology, determination of high-resolution structures of proteins serve as the foundation upon which rational drug design is built. Following discovery of new drug candidates, controlling or preventing crystallization is an essential step to ensure bioavailability and efficacy. In both applications, the unique symmetry relationships arising in nonlinear optical interactions provide exquisite selectivity for detection and quantification of chiral crystals. Topics to be covered in the presentation will include opportunities and challenges in designing nonlinear optical instrumentation capable of supporting routine, benchtop measurements in biology and pharmaceutical science.
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