Ohio University’s Chemistry and Biochemistry Colloquium Series presents Dr. Amar Flood on “Anion Recognition with Shape Persistent Macrocycles”on Monday, Sept. 19, at 4:10 p.m. in Clippinger Laboratories Room 194.
Dr. Amar Flood
Flood is the James F. Jackson Professor of Chemistry and Luther Dana Waterman Professor at Indiana University.
Abstract: Shape persistent macrocycles are attractive multifunctional molecules bearing inner cavities for anionic guests, outer surfaces that can direct hierarchical self-assembly and persistent rigidities for easy property analysis. This talk will present on recent lessons with triazolophanes and the genesis of novel classes of rigid macrocycles, including the cyanostar and tricarbazole macrocycles. The cyanostars help generalize and deepen our understanding and use of CH hydrogen (H) bond donors in anion recognition, as exemplified by the 1,2,3-triazoles in triazolophanes. Such H-bonding is normally overlooked in receptor design – interpretation: CH donors are 2nd-class members of the H-bonding citizenry. However, the gram-scale one-pot preparations of cyanostars and the extremely large stabilities displayed when chelating traditionally non-coordinating anions, like ClO4– (~70 kJ mol–1), give cause for re-evaluation. We contend that the consideration of CH donors for anion binding can bring a wholly new cross section of carbon-based building blocks into play for the creation of multifunctional macrocycles. These possibilities will be highlighted with demonstrations, such as, anion-templated rotaxanes, redox switches and hierarchical self-assembly; examples that underpin the continued employ of macrocycles in the future growth of supramolecular chemistry.
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